At first, both groups of women reported difficulty falling asleep 1 in 3 nights, waking up frequently 2 out of 3 nights, and waking up first 1 in 3 nights a week. More than 70% of women in both groups reported sleep disorder at least 3 times a week. There were no significant changes in the 1- and 2-year milestones.
Sleep disorders are common in the United States, with 9 million Americans reporting drug use. Poor quality sleep is associated with many chronic conditions, such as diabetes, high blood pressure, pain, and depression, and various medications are prescribed to help patients.
They include benzodiazepines, Z drugs (selective BZD receptor agonists that include zolpidem, zaleplon, and eszopiclone), and other drugs used off-label and intended primarily for conditions such as anxiety and depression.
Data from clinical trials indicate that many of these drugs work in the short term (up to 6 months), but insomnia can be chronic and many take these medications for longer, according to the researchers. The data were used from the Nationwide Women’s Health Study, a long-term multicenter study in the United States that analyzed the biological and psychosocial changes that occurred during menopause. Participants had a mean age of 49.9 years. The group was ethnically diverse, with half of the participants white.
Mean scores of difficulty falling asleep, waking frequently, and waking up early in the morning were similar for both groups throughout the study. Neither one-year changes were statistically significant for either group and there were no significant differences between users and non-users. The 2-year results were similar. Scores were based on a 5-point Likert scale, with 1 representing no difficulty and 5 representing difficulty 5-7 nights a week.
The difficulty in initiating sleep for drug users was 2.7 (95% CI, 2.5-2.9) at baseline and 2.6 (95% CI, 2.4- 2.8) at 1 year. For non-users, the scores were 2.6 (95% CI, 2.5-2.7) at the beginning and 2.3 (95% CI, 2.2 -2.5) at the one year note.
For frequent awakening, drug user scores were 3.8 (95% CI, 3.6–3.9) at baseline and 3.6 (95% CI, 3.4–3). , 8) to the qualification of one year. For non-users, the scores were 3.7 (95% CI, 3.6-3.9) at the beginning and 3.5 (95% CI, 3.3-3.6) at the one year note.
For waking up early in the morning, drug user scores were 2.8 (95% CI, 2.6-3.0) at both the beginning and the one-year mark. For non-users, the scores were 2.8 (95% CI, 2.6-3.0) and 2.5 (95% CI, 2.3-2.6) on the one-year grade .
Solomon DH, Ruppert K, Habel LA, et al. Prescription drugs for sleep disorders in middle-aged women for 2 years of follow-up: a retrospective SWAN cohort study. BMJ Open. 2021; 11: e045074. doi: 10.1136 / bmjopen-2020-045074